Abstract
Objectives:The purpose of the present study was to investigate the anti-inflammatory properties of aqueous extract of the leaves of H. integrifolia, Planch.Materials and Methods:The hind paw edema was produced in rats by subplanter injection of carageenan. The aqueous extract of H. integrifolia, Planch. (AHI) at dose (250 and 500 mg/kg p.o) was given to observe % inhibition of paw edema which were comparable with indomethacin (10 mg/kg p.o) used as a reference drug.Results:The extract administered orally at doses of 250 and 500 mglkg p.o produced a significant (P < 0.05) dose dependent inhibition of edema formationConclusions:A significant % inhibition of paw edema by the aqueous extract of leaves of H. integrifolia, Planch. and its almost nearby same % inhibition with indomethacin suggest its usefulness as an anti-inflammatory agent.
Highlights
It is an important pollen allergen of India and sensitizes almost 10% of the atopic population in Delhi.[2] Some recent explorations have been reported on this plant in which antiviral activity,[3] antioxidant, antimicrobial and wound healing activities[4] are important
The present study was under taken to evaluate the anti-inflammatory activity of aqueous extract of Holoptelea integrifolia, Planch. (AHI)
The experimental protocol was approved by the Institutional Animal Care and Use Committee (IACUC) of the SRM University, Kattankulathur, Tamil Nadu, India
Summary
It is an important pollen allergen of India and sensitizes almost 10% of the atopic population in Delhi.[2] Some recent explorations have been reported on this plant in which antiviral activity,[3] antioxidant, antimicrobial and wound healing activities[4] are important. The leaves and stem bark of this plant were used by local people for skin diseases, obesity,[5] cancer[6] and for wound healing in the form of paste. The fresh material, either stem bark or leaves of the plant, is applied as paste externally twice or thrice a day for wound-healing.
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