Studies on anti-inflammatory agents. 3. Effect of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6,7-tetrahydrothieno(2,3-c)pyridine (Y-3642) on pyretic reaction, vascular permeability and granuloma formation in experimental animals

Abstract

2-Amino-3-ethoxycarbonyl-6-benzyl-4, 5, 6, 7-tetrahydrothieno [2, 3-c] pyridine hydrochloride (Y-3642 HCl) inhibited the exudate formation in formalin-induced peritonitis and granuloma pouch test in rats, and dye leakage into the peritoneal cavity in Whittle test in mice. Y-3642·HCl had no effect on normal rectal temperature of rabbits, but displayed higher antipyretic potency than aminopyrine. This compound had no inhibitory effect in granuloma formation and did not delay the process of wound healing in rats. There was no difference in anti-edematous activity of this compound between intact and adrenalectomized rats. From these results it was suggested that the anti-inflammatory activity of this compound was not mediated by the adrenocortical functions.