Studies on an application of the complementary tristimulus colorimetry using the internal standard to the dissolution test of tablet (author's transl)

Abstract

Complementary Tristimulus Colorimetry (CTS) was applied in dissolution tests of multi-ingredient tablets. In the test, internal standards were used for improved accuracy. Two kinds of internal standard situations were studied, in one, the absorption spectra of tablet components and the internal standard overlapped, and in the other, they did not. In the latter situation, carbazochrome sodium sulfonate, and in the former, chloperastine hydrochloride was used as the internal standard for the dissolution test of EA tablets which contained aspirin and ascorbic acid. Our results indicate that the internal standard method is useful in the dissolution test.