Abstract
The study investigated the acute and sub-chronic effects of the n-hexane seed extract of RICOM-1013-J in biochemical and haematological parameters of mature adult female Wistar rats with an average weight of 110 g. The objective of the study was to determine the immediate, short-term and prolonged toxicological profile of the extract. Thirty-four (34) adult female rats were randomly divided into three groups (n=8) of rats. Two animals (group I) and coded A received 0.2 ml/100 g rat of vegetable oil, and served as control. Two other animals (group II) coded B received 5 mg/kg, subcut. of the extract, a third set of animals (group III) code C was administered 20 mg/kg, subcut. The last two animals (group IV) coded D were injected with 30 mg/kg, subcut. of the extract. The same dosage regimen was administered to a different set of animals of equal number in groups II and III in pairs, and coded accordingly. SGOT, SGPT, urea, total protein, alkaline phosphatase, bilirubin and haematological assays were carried out at weeks I, IV and VIII in groups I, II and III respectively. Findings from the experiment showed no significant (P>0.05) differences in the mean values of the biochemical parameters and haematological indices test groups relative to control. The study concluded that the n-hexane seed extract of RICOM-1013-J is relatively safe in rats when administered subcutaneously.
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