Abstract
Summary The nature and origin of an ultrafiltrable toxicity-enhancing factor present in toxic intestinal strangulation fluid has been investigated. The factor increases the toxicity of suspensions of E. coli as tested by intraperitoneal injections in mice. The factor is probably of protein nature, as it can be removed from a fluid by sedimentation with trichloroacetic acid (TCA). It is not dialyzable but is destroyed by heating to 100° C. for 15 minutes. The factor cannot be a bacterial product, since it is present also in the sterile strangulation fluid from germfree animals, and since it does not appear in nontoxic strangulation fluid in which E. coli is cultured for 24 hours. The toxicity of saline suspensions of E. coli is not enhanced by the addition of plasma or by the addition of erythrocytes (or of hemolysate) to a hemoglobin concentration comparable to that found in most of the toxic strangulation fluids. It is concluded that the toxicity-enhancing factor (or factors) present in toxic strangulation fluid probably originates from disintegrating tissue in the strangulated loop of intestine.
Published Version
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