Abstract
The reactions of 6-[(dimethylamino)methylene]aminouracil 1 , with various heterocumulenes such as aryl isocyanates and isothiocyanates give rise to novel pyrimido[4,5- d]pyrimidines in excellent yields, after elimination of dimethylamine from the (1:1) cycloadducts and tautomerisation. This procedure provides a convenient method for direct synthesis of pyrimido[4,5- d]pyrimidine derivatives under thermal conditions.
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