Studies on 6-azauridine and 6-azacytidine—V.: Influence of 6-azacytidine on prenatal development in mice

Abstract

6-Azacytidine interrupts pregnancy in albino mice with an optimum effect between the 5th and 7th day; after the 15th day the administration is ineffective. Three consecutive doses are more effective than a single one. The efficacy of the compound undergoes seasonal variations. Malformations of the tails were observed in the 3rd pregnancy when the drug was administered during consecutive pregnancies. F 1-females without malformations from the first pregnancy mated with random males and given the drug during the whole gestation period had offspring with the same tail malformation after the first pregnancy.