Abstract
Abstract Actinomycin D (C1) has been synthesized by a route involving the ester formation between two peptide fragments, (2S,3S)-1-(2-nitro-3-benzyloxy-4-methylbenzoyl)-3-methyl-2-aziridinecarbonyl-d-valylproline t-butyl ester and N-benzyloxycarbonylsarcosyl-N-methylvaline, via a ring-opening reaction of aziridine. Cyclization, followed by reduction and oxidation, gave actinomycin D (C1). The synthetic actinomycin D (C1) was indistinguishable from natural substance as regards physical properties and biological activity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
