Studies of wool growth responses to 2-hydroxy-4-(methylthio) butanoic acid, Alimet, an analogue of methionine

Abstract

An analogue of DL-methionine, Alimet, was evaluated for its commercial potential for increasing wool growth in Merino sheep in pen and grazing experiments. This was done by administering Alimet as a drench, in drinking water, or via rumen or abomasal fistula, and measuring wool growth rate and plasma methionine concentrations. In vivo data indicated that significant wool growth responses (23-35%) to Alimet as a drench or in drinking water occurred at low rates (estimated 5-6 g/sheep.day) of basal wool production when sheep were fed a lucerne diet to maintain liveweight. At higher rates of clean wool growth (10-12 g/sheep.day) when sheep were eating above-maintenance diets (lucerne ration or pasture), Alimet treatment was associated with variable and reduced response. A significant (P<0.05) negative correlation (r2 = 0.699, n = 11) between wool growth responses (x � s.d. = 0.11 � 0.067) to the 3 mL dose rate of Alimet and wool growth in control treatments (y �: s.d. = 0.70 � 0.202) confirmed the above trend. Four hours after administration of Alimet via either rumen or abomasal fistula, comparative plasma concentrations of methionine, 28 and 168 �mol/L respectively, suggest that Alimet is susceptible to degradation in the rumen. The corresponding values for DL-methionine, via either rumen or abomasal fistula, were 64 and 350 �mol/L, respectively. The small rises (40%) in plasma methionine values associated with significant increases in wool production indicate that a dose of 3 mL is as effective as 4 mL of Alimet when the basal nutritional regime is limiting. While administration of Alimet in drinking water during dry seasons is possible, the profitability of supplementation would need to be tested further.