Abstract
The effects of solid dispersions (SD) on the solubility of rutin were studied. Rutin and its SD with polyethylene glycol 1500 and polyvinylpyrrolidone 10000 were studied. Preparation of SD increased the solubility and rate of dissolution of the active substance. The solubility of rutin from SD increased by a factor of 52. The physicochemical methods used here suggested that improvements in rutin release from SD result from decreases in crystallinity and formation of solid solutions of drug in polymer.
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