Abstract
In 87 rabbits, some of which received intravenously at various intervals small, and some large, doses of killed staphylococci, the following findings were obtained. 1. There occurred a hyperplasia of lymph nodes, spleen and thymus, that is to say, a status thymicolymphaticus. This phenomenon is explained as due to immediate local irritation caused by bacteria and their products and by certain "toxins" partly of exogenous, partly of endogenous, origin. 2. The lymphocytosis which appeared was parallel in time and degree with the hyperplasia of the peripheral lymph nodes (axillary, popliteal and cervical lymph nodes) and probably originated in the pseudo-secondary nodules of these nodes. 3. There occurred intense mesenchymal reaction in the vascular connective tissue of the lungs, liver and spleen and after large doses slighter ones in adrenals, kidneys and heart. These reactions correspond with Oeller's adventitial reactions and Siegmund's intima proliferations. In the interstitial tissue of these organs as well as in the walls of the minor vessels proliferations of cells, partly of the type of lymphocytes and plasma cells, partly of that of histiocytes and reticulo-endothelial cells, appeared, which, after large doses, were mixed with many giant cells of Langerhans' type. After small doses lymphocytes and plasma cells predominated, after large doses histiocytes and reticulo-endothelial cells. Because these reactions occurred immediately after the first injection, they can be regarded as primary reactions of the organism to bacteria and their products.
Highlights
MethodsThe material used consisted of 87 treated and 27 normal male rabbits. For masons already given [1], animals as nearly alike in color and weight as possible were chosen.The animals were treated partly with small and partly with laxge doses (in a manner determined by previous experiments during studies of immunization)
The description of the curves of the lymphocytes can be given in a few words
In the differentiation of lymphocytes from monocytes and histiocytes in blood smears, all mononuclear cells which were not recognized with certainty as monocytes or histiocytes, were counted as lymphocytes
Summary
The material used consisted of 87 treated and 27 normal male rabbits. For masons already given [1], animals as nearly alike in color and weight as possible were chosen.The animals were treated partly with small and partly with laxge doses (in a manner determined by previous experiments during studies of immunization). The animals of series A were treated intravenously with varying doses of 20 hour whole broth cultures of Staphylococcus aureus killed by heating for 2 hours at 60°C. These animals will be referred to as treated with small doses. The animals of series B received intravenously killed staphylococci, which had been centrifuged and diluted with saline soIution, so that 1 ce. These animals will be referred to as treated with single large doses
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