STUDIES OF THE CORRELATION OF THE TAFI GENE WITH ARTERIAL HYPERTENSION IN PATIENTS WITH CORONARY HEART DISEASE

Abstract

Objective: The purpose of our work was to study the associative relationship and role of the thrombin-activated fibrinolysis inhibitor (TAFI) with hypertension and the severity of coronary heart disease. Design and method: The object of the study was 2 groups of patients, 1 group of 35 people with Stable angina and 2 group of 33 people with Unstable angina who voluntarily signed the information consent. The study was conducted by a prospective method in the TMA clinic. in group 1, grade 2 hypertension (40%) and grade 1 hypertension (31.4%), grade 3 hypertension (14.3%) prevail. smoking – 37.1%, inactivity – 48.5%, as well as severe Anxiety-depressive syndrome – 34.3%. In group 2, hypertension 2 (13.6%), hypertension 1 (27.1%) and hypertension 3 degrees (12.1%). smoking and sedentary lifestyle – 45.5% each; overweight – 30.3%. All patients underwent a genetic blood test for TAFI gene polymorphism. In group 2 of patients with NS, the indicators of hypertension of 1 and 2 degrees became reliable, which means that the contribution of arterial hypertension to the development of complications of coronary heart disease is unambiguous. According to EchoCG data, no significant differences in EDV and ESV of LV, as well as LV EF parameters were revealed in the studied groups. Results: According to the results of our study, in both groups of respondents from groups 1 and 2, the picture of correlation dependence turned out to be as follows: a strong correlation was found between hypertension, hereditary burden, smoking, inactivity, hypercholesterolemia, as well as malnutrition and patients with diabetes in both groups. The average correlation is determined with hypercholesterolemia in the blood and Anxiety depressive syndrome. Conclusions: Together with the factors of coagulation hemostasis and hereditary predisposition to them, the doctor should pay attention to the prevention of Arterial hypertension and smoking in patients with Stable angina pectoris and Unstable angina pectoris.