Abstract
Excessive norepinephrine (NE) release has been found in patients with MDD after postural challenge. We have further evaluated SNS function by measurement of epinephrine (EPI) release in addition to NE, heart rate (HR), and blood pressure (BP) responses to postural challenge. Patients (N = 44) had significantly higher levels of EPI at rest and at three minutes of standing (p < .05) than controls (N = 40). We did not find significant differences in NE levels. HR was significantly higher in the depressed group at three minutes (p < .05), paralleling the EPI rise. BP was comparable in both groups. Within groups EPI release did not correlate with NE release in the depressed group, but did for controls (p < .05). These findings suggest that patients had a faster sympathomedullary response to a postural challenge and have dysregulated adrenomedullary reactivity or altered central regulation of the SNS.
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