Abstract
The most important task in the field of medical diagnostics is the creation and application of new diagnostic tools and methods, as well as diagnosis of physiological processes. To solve this problem, one may use the optoacoustic (OA) effect – thermooptical excitation of acoustic waves in a liquid medium under laser radiation absorption. This study utilizes numerical methods for modeling processes of oxygen saturation and red blood cells aggregation in the blood. Models of oxygenated red blood cells and their distribution in the blood are constructed using the Monte Carlo method. The acoustic signal from oxygenated and deoxygenated red blood cells was simulated at various levels of oxygen saturation. It was found that the level of spectral power density of the acoustic signal varies significantly and allows one to estimate the percentage of oxygen saturation of red blood cells in the blood with implementation of OA method. A model for the aggregation of red blood cells, combining red blood cells into clusters by hexagonal packing, was developed to increase compactness. It was found that using the OA method, it is possible to determine the level of red blood cells aggregation and of hematocrit level .
Highlights
In the conditions of development and improvement of medicine, it becomes necessary to develop and study new diagnostic methods, one of which is the optoacoustic (OA) effect
The aim of the work is the modeling of red blood cells considering oxygen saturation using the Monte Carlo method, development of a mathematical model of red blood cell aggregation by hexagonal packing, and calculation of acoustic signals generated as a result of OA conversion from red blood cells to establish the possibility of aggregation level and oxygen saturation estimation
A large range of simulated levels of saturation is given in order to show the possibilities of the OA method for recording oxygen saturation
Summary
In the conditions of development and improvement of medicine, it becomes necessary to develop and study new diagnostic methods, one of which is the optoacoustic (OA) effect. A numerical analysis of the optical characteristics of biological media provides necessary information for effective diagnosis. Modern methods for determining the optical characteristics of biological media require implementation of in vitro analysis, i.e. determination of attenuation by spectrophotometry, fluorescence spectroscopy, Raman spectroscopy, etc. The increase in aggregation may occur as a result of “side effects” of medications and may lead to blockade of small vessels by aggregates, and difficulties in transporting oxygen in human blood. In this regard, the analysis of aggregation level and oxygen saturation must be carried out for patients undergoing treatment in medical institutions [5,6,7]. To measure the level of red blood cell aggregation and oxygen saturation in the
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