Abstract
Summary 1 The rationale, and application of the radioactive phosphorus uptake ratio test in the diagnosis of intra-ocular and cutaneous melanomata, has been described and illustrated. 2 Preliminary results recorded for 27 patients (12 with cutaneous, and 15 with ocular disease) indicate that the 32P uptake test is useful, a differential uptake of 1.3 being taken as significant. 3 A correlation has been obtained between the 32P uptake ratio, and the tumour nucleoprotein content based on measurements of volume and density of tumour cell nuclei. 4 Attention is drawn to possible biological differences between melanomata of the iris and those of the choroid. 5 The correlation of 32P uptake ratios with histological diagnosis of malignancy in these tumours, is discussed.
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