Abstract
Reaction of mono- and di-esterified phosphoramidate with nitrous acid or isoamyl nitrite was investigated. While in the monoesterified phosphoramidate the rection enhanced intensively by both nitrous acid and isoamyl nitrite, in the case of dibenzylphoramidate nitrous acid did not bring about hydrolysis reaction. Order of the rate of the reacton with diesterified phosphoramidate indicates direct attack of NO+ on NH2. Various in termediates of the reaction of thymidine 5'-phosphoramidate with isoamylnitrite were isolated by the DEAE-cellulose chromatography.
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