Abstract
Lymphocytes in mouse and rat popliteal lymph nodes were labeled with tritiated thymidine after an immunologic stimulus. Thirty days later the animals were given one or a series of injections of heterologous anti-lymph node or anti-thymus serum. The proportion of persistently labeled lymphocytes in the popliteal nodes was determined one or two days later. The proportion of long-lived lymphocytes in the nodes did not change even when a significant lymphopenia was produced. Since the nodes were depleted of small lymphocytes, labeled cells must have emigrated. These data support the hypothesis that non-migrating lymphocytes are not qualitatively different from the circulating lymphocyte pool.
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