Abstract
SummaryThe average insensible water loss of a group of unburned rats was compared to that of three groups of rats subjected to 20 percent burns.The average daily insensible water loss of the burned rats (25.7 gm was significantly greater than that of the unburned controls (10.3 gm).The application of 3 to 5 gm of Sulfamylon to the eschar did not reduce the average daily insensible water loss of the burned rats (29.9 gm).Excision of the eschar two hr after burning followed by the application of an impermeable prosthetic skin reduced the average daily insensible water loss to 12.7 gm.Sulfamylon acetate at room temperature loses approximately 37 percent of its weight in 48 hr.Sulfamylon acetate at body temperature loses about 47 percent of its weight in four hr.Sulfamylon acetate did not reduce the insensible water loss or oxygen consumption of a normal volunteer or of a patient who sustained a 25 percent, second degree burn.
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