Abstract
Summary Allergic encephalomyelitis (AE) may be induced in rats by sensitization to either homologous or heterologous (guinea pig) spinal cord plus incomplete adjuvant, lacking killed mycobacteria. The disease induced in this manner is comparable in all respects to that induced conventionally with spinal cord plus complete adjuvant, containing mycobacteria. Rats occasionally develop AE following a single injection of the heterologous spinal cord alone. In contrast to rats, mycobacteria are important for induction of AE in guinea pigs. Guinea pigs sensitized to heterologous (rat) spinal cord plus incomplete adjuvant only occasionally exhibit clinical signs and/or lesions of the disease. None of the animals sensitized to homologous spinal cord plus incomplete adjuvant developed AE. Implications of these observations with respect to pathogenesis of AE are discussed.
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