Abstract
Abstract The rate of acetylation of sulfadiazine (SD) in rabbit liver homogenates has been studied in 51 animals. These studies reveal that rabbit liver homogenates have different rates of acetylation of SD of either low, intermediate, or high hepatic acetylase activity. The metabolic inactivation rate for SD in vitro is significantly correlated with the acetylation rate of SD in vivo. These different amounts of acetylase activity might correspond to the homozygous recessive, heterozygous, and homozygous dominant conditions, respectively, and suggest that hepatic SD acetylase may be controlled by a simple Mendelian autosomal dominant characteristic.
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