Abstract
AbstractHydrolysis of DNA is an important enzymatic reaction, but it is exceedingly difficult to mimic in the laboratory because of the stability of hydrolysis of DNA. In this paper, the cleavage activity of complexes formed between Cu(II) and four different amino acid or amino acid methyl ester on DNA is studied by gel electrophoresis. It is found that DNA could be cleaved by Cu(II)‐L‐His and Cu(II)‐L‐His methyl ester complexes and the efficiency of cleavage is largely dependent on the metal ion‐to‐ligand ratio. Further experiments show that the cleavage of DNA mediated by Cu(II)‐L‐His complexes occursvia a hydrolytic mechanism and the active chemical species that affects DNA cleavage is proposed to be MI2H+ and MI2H22+.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
