Abstract
The effects of sinus-nerve stimulation on the blood pressure and heart rate were studied in unanaesthetized normotensive dogs. Care was taken that the dogs should be as unaffected as possible by the experimental measures. Stimulation frequencies of 10–100 Hz were employed, with the dogs running on a treadmill and at rest. At work no further blood-pressure reduction in the steady state was obtained when the stimulation frequencies were increased above 30–50 Hz, while the initial blood-pressure reduction at the onset of the CSNS (carotid-sinus-nerve-stimulation) increased up to stimulation frequencies of 70–80 Hz. A greater initial heart-rate reduction was obtained in the range 60–100 Hz than at lower stimulation frequencies. The initial and steady-state blood pressures were in complete agreement with the reported observations of sympathetic outflow during CSNS. No changes in the effects of CSNS were observed during 9 months of repeated stimulation.
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