Abstract
Scrapie occurring in certain Scottish sheep stocks is an infective disease caused by a filtrable virus of undetermined size. The disease is transmissable in series from sheep to sheep; in the present investigation nine successful passages have been made. In some instances, the incubation period of the experimental disease, resulting from intracerebral inoculation, was approximately four months, but usually it was about five months. The virus remains viable in the desiccated state at 0° to 4°C for long periods; in each of two experiments virus survived in dried brain tissue for a period of over two years. In addition to a slight and variable degree of vacuolation of the neurons in the medulla oblongata the histological changes observed in the central nervous system of sheep experimentally infected were indicative of the existence of subacute or chronic meningoencephalitis.
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