Abstract
The (9 S)-macrolide 1 (P = TBS) was prepared in 14 steps (5% yield) with 63% overall ds starting from the ethyl ketone ( S)- 2. The C 1–C 7 and C 8–C 13 segments, 3 and 4, were obtained via boron enolate aldol reactions mediated by (+)- and (−)-(Ipc) 2BOTf, respectively.
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