Abstract
1. In non-nephrectomized animals the addition of adrenalin to sodium chloride solutions or to mixtures of sodium chloride and calcium chloride solutions increases the amount of urine and of ascites, and diminishes the intestinal fluid (this diminution takes place only with mixtures of solutions of sodium chloride and calcium chloride, the quantity of intestinal fluid remaining approximately unchanged in the sodium chloride series). 2. In nephrectomized animals the addition of adrenalin to sodium chloride solutions or to mixtures of sodium chloride and calcium chloride solutions again increases the ascites and diminishes the amount of intestinal fluid in both sodium chloride and sodium chloride plus calcium chloride series. 3. We find, therefore, a summation of the action of calcium chloride and adrenalin in regard to their influence upon the formation of ascites, an antagonistic action in regard to the elimination of urine; here the influence of calcium chloride in diminishing the urine is more potent than is the action of adrenalin in increasing the amount of urine. The adrenalin decreases the elimination of fluid into the intestines and in this case we note a summation of the actions of calcium chloride and of adrenalin. 4. We see, therefore, that adrenalin and calcium chloride influence the amount of ascitic fluid and of intestinal fluid in the same direction. The amount of urine is, however, decreased by calcium chloride and increased by adrenalin. 5. If we increase the rapidity of inflow of the solutions and simultaneously decrease proportionately the time of the infusion, the amount of ascites and intestinal fluids in nephrectomized animals remains approximately unchanged, as compared with the amounts obtained at the usual rate of inflow.
Highlights
In a series of non-nephrectomized animals which were infused with o.85 per cent. sodium chloride solutions to which adrenalin had been added, we found per I,OOO c.c. of fluid infused 520 c.c. of urine, and per I,ooo c.c. of fluid retained 79 c.c. of ascites and 58 c.c. of intestinal fluid, as compared with animals infused with pure solutions of sodium chloride showing 420 c.c. of urine per I,OOO c.c. of infused fluid and 68 c.c. of ascitic and 53 c.c. intestinal fluid per,ooo c.c
We find in nephrectomized animals in which mixtures of sodium chloride and calcium chloride solutions plus adrenalin have been infused, per I,ooo c.c. of injected fluid, 65 c.c. of ascitic and 46 c.c. of intestinal fluid, as compared with I45 c.c. of ascitic and 59 c.c. of intestinal fluid in animals infused with mixtures of sodium chloride and calcium chloride solutions in our earlier experiments
In non-nephrectomized animals the addition of adrenalin to sodium chloride solutions or to mixtures of sodium chloride and calcium chloride solutions increases the amount of urine and of ascites, and diminishes the intestinal fluid
Summary
These figures may be compared with the results obtained in our earlier experiments when mixtures of sodium chloride and calcium chloride solutions were infused into non-nephrectomized animals; in these experiments we found 175 c.c. of urine per I,ooo c.c. of infused fluid, and go c.c. ascitic and 47 c.c. intestinal fluid per I,ooo c.c. of retained fluid. Sodium chloride to which adrenalin had been added our results show, per I,OOO c.c. of infused fluid, II9 c.c. of ascitic and 54 c.c. of intestinal fluid, as compared with Io9 c.c. of ascitic and 94 c.c. of intestinal fluid in our earlier series of experiments in which pure solution of sodium chloride was injected into nephrectomized animals.
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