Abstract
A stereoselective synthesis of the C1–C21 fragment of the non-immunosuppressive immunophilin-binding natural product, antascomicin A was achieved using, as key steps, highly stereoselective Aldol reactions to build the C1–C17 fragment and a Nozaki–Hiyama–Kishi reaction to couple it with the remaining C18–C21 moiety.
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