Abstract
For a long time the medical profession has felt the urgent need of a simple and certain diagnostic test for syphilis. The wide distribution of syphilis, the fact that syphilis can and does simulate many other diseases, and the fact that even experts are at times baffled in their diagnosis, have emphasized the necessity for a simple and certain diagnostic test for this disease. After von Pirquet announced his reaction for tuberculosis, many investigators, among them Finger, Wolff-Eisner, Nicholas and others, attempted to obtain a specific reaction by applying extracts of syphilitic tissues to the skin of syphilitic patients. Neisser and Meirowsky had found that normal hepatic extract could not only occasionally give a similar exanthematic result as syphilitic extract, but that the test might also give a positive result in patients in whom there was no reason to suppose the existence of syphilis. In spite of some rather encouraging
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