Studien zur Chemie O,N‐ und S,N‐haltiger Heterocyclen, 10. Mitt1): Synthese und biologische Aktivität von 2‐substituierten 2‐Ethylbenzoxazolen

Abstract

2-Vinylbenzoxazole (3) is obtained by condensation of acrylic acid with 2-aminophenol in a mixture of phosphorus pentoxide/methansulfonic acid. Interaction of 3 with N-, O-, and C-nucleophiles yields 2-substituted 2-ethyl-benzoxazoles. Compounds 8a, 8b and 8e show analgetic activity in mice. Moreover, fungicide, insecticide and nematocide activity of some compounds is found.