Studie zur arteriosklerosegenese beim Hanford-Miniaturschwein unter normalen und experimentellen bedingungen: Teil 1. Pathologische anatomie und histologie

Abstract

The Handford-miniature swine shows a pronounced inclination to develop spontaneous arteriosclerosis like other domestic porcine breeds. In the reported studies two groups of miniature swine were fed a standardized basic diet, which has been supplemented in one group by 10% palmoil-stearin of known chemical composition. One-half of the animals of each group was kept in stables under standardized climatic conditions and the second half in wooden field boxes with free runs. The results of the study show that the kind of climatic environment seems to have no significant influences on the development and severity of arteriosclerosic lesions in contrary to the different diets. Whereas the aortic lesions of the control groups had reached only a stage of merely uncomplicated intimal sclerosis (physiosclerosis!), in the experimental group the fat diet obviouslv has caused complicated lesions comparable to early human arteriosclerosis. After 38 months an atheromatous-necrotic stage has developed. The role of smooth muscle cells within the pathogenesis of intimal sclerosis as well as the problems of lipid and mucopolysaccharide metabolism of the arterial wall are discussed on the basis of histomorphology.