Abstract
Recent immunological and transgenic advances are a promising alternative using limited materials of human origin for transplantation. However, it is essential to achieve social acceptance of this therapy. To analyze the attitude of nursing students from Spanish universities toward organ xenotransplantation (XTx) and to determine the factors affecting their attitude. Type of study: A sociological, multicentre, and observational study. Nursing students enrolled in Spain (n=28,000). A sample of 10566 students estimating a proportion of 76% (99% confidence and precision of ±1%), stratified by geographical area and year of study. Instrument of measurement: A validated questionnaire (PCID-XenoTx-RIOS) was handed out to every student in a compulsory session. This survey was self-administered and self-completed voluntarily and anonymously by each student in a period of 5-10min. descriptive analysis, Student's t test, the chi-square test, and a logistic regression analysis. A completion rate: 84% (n=8913) was obtained. If the results of XTx were as good as in human donation, 74% (n=6564) would be in favor and 22% (n=1946) would have doubts. The following variables affected this attitude: age (P<0.001); sex (P<0.001); geographical location (P<0.001); academic year of study (P<0.001); attitude toward organ donation (P<0.001); belief in the possibility of needing a transplant (P<0.001); discussion of transplantation with one's family (P<0.001) and friends (P<0.001); and the opinion of one's partner (P<0.001). The following variables persisted in the multivariate analysis: being a male (OR=1.436; P<0.001); geographical location (OR=1.937; P<0.001); an attitude in favor of donation (OR=1.519; P<0.001); belief in the possibility of needing a transplant (OR=1.497; P=0.036); and having spoken about the issue with family (OR=1.351; P<0.001) or friends (OR=1.240; P=0.001). The attitude of nursing students toward organ XTx is favorable and is associated with factors of general knowledge about organ donation and transplantation and social interaction.
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