Abstract
THERE have been conflicting reports concerning the action of strychnine on the recurrent inhibition of single cortical pyramidal tract (PT) neurones of the cat. On one hand the recurrent inhibitory hyperpolarization is apparently depressed, or even reversed in polarity, by strychnine administered topically to the cortical surface1–4. In contrast, when administered intravenously in doses sufficient to eliminate most types of spinal postsynaptic inhibition, strychnine hydrochloride has no effect on cortical recurrent inhibition, which in the absence of intracellular records can be measured as the ‘pause’ induced, by brief tetanic stimulation of the medullary pyramids, in firing which is spontaneous or evoked by amino-acids5. Differences in the susceptibility of inhibitory processes to strychnine may reflect the operation of different inhibitory transmitters, and thus it is important to determine whether or not cortical inhibition resembles spinal postsynaptic inhibition in its sensitivity to strychnine.
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