Abstract
We describe two cases of strumal carcinoid of ovary, which is an extremely rare ovarian germ cell tumor composed of an intimate mixture of thyroid and carcinoid tissues. The first case involved a 63-year-old woman, who presented with a 1-month history of abdominal distension and unintentional weight loss (5 kg). Abdominal and chest computed tomography revealed right ovarian tumor and bilateral pleural effusion. Her thyroid-stimulating hormone level was slightly lower 0.475 μIU/mL (normal range: 0.55 - 4.78 μIU/mL); however, the levels of FT3 and FT4 were normal. Intraoperatively, the right ovary was enlarged (8.0 cm × 7.0 cm), with a smooth surface and intact capsule. Bilateral salpingo-oophorectomy with a total abdominal hysterectomy and an appendectomy was performed. The second case was a 54-year-old woman, in whom pelvic mass was recognized 2 months before. Intraoperatively, the left ovary was dumbbell-shaped (20.0 cm × 9.0 cm × 9.0 cm) and connected to two masses (9.0 cm × 8.0 cm and 8.0 cm × 7.0 cm, respectively). Her thyroid function test was normal (0.70 μIU/mL). Total abdominal hysterectomy, partial omentectomy, and pelvic adhesion lysis were performed. In both patients, intraoperative frozen section suggested strumal carcinoid of the ovary (stage IA). Ovarian strumal carcinoid should be included in a differential diagnosis of adnexal masses. The prognosis is considered good.
Highlights
Strumal carcinoid of the ovary is an extremely rare ovarian germ cell tumor, featuring an intimate mixture of thyroid and carcinoid tumoral tissues
We describe two cases of strumal carcinoid of ovary, which is an extremely rare ovarian germ cell tumor composed of an intimate mixture of thyroid and carcinoid tissues
In 1992, Motoyama et al [15] were the first to report a case of severe constipation accompanying primary ovarian carcinoid; they illustrated how the constipation was caused by the overproduction of an inhibitory protein, peptide YY (PYY), by the tumor cells and not by the pressure effects of the tumor itself
Summary
It is most commonly found in the fifth and sixth decades of life and accounts for 0.3% - 1% of all ovarian tumors and 3% of mature teratomas [2] [3]. We report two interesting cases of patients with primary strumal carcinoid of the ovary who had been admitted to our hospital’s gynecological department in 2018. We discuss the clinical and histopathological features, treatment, and prognosis of these cases to enhance the overall understanding of strumal carcinoid of ovary and its importance in differential diagnosis
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