Abstract
Structures of the O-specific polysaccharide chains of lipopolysaccharides from Proteus group OX strains (serogroups O1–O3) used as antigens in Weil-Felix test for diagnosis of rickettsiosis, were established. From them, the acid-labile polysaccharide of Proteus vulgaris OX19 (O1) is built up of the following branched pentasaccharide repeating units connected via a phosphate group: where QuiNAc stands for 2-acetamido-2,6-dideoxyglucose ( N-acetylquinovosamine). The basis of serospecificity of the Proteus group OX antigens and their cross-reactivity with human anti-rickettsial antibodies is discussed.
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