Abstract
A known withanolide steroid cilistol G (1) [1] and six new related withanolides, capsisteroids A-F (2- 7), were isolated from the acetone extract of the leaves of Solanum capsicoides. The structures of compounds 1- 7 were elucidated by extensive spectroscopic analysis, including 2D NMR spectroscopy (COSY, HSQC, HMBC, and NOESY). The structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. It was found that 1, possessing 26 S configuration, is not stable for prolonged periods of time, and was gradually epimerized to 26 R and finally reached to a 3:1 26 S/R diastereomers. These compounds were evaluated for their cytotoxicity against the proliferation of a limited panel of cancer cell lines. Further, anti-inflammatory activity of compounds 1- 7 was studied by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.
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