Structure–function relationship: assessment of macular ganglion cell complex with FD‐OCT and standard automated perimetry

Abstract

AbstractPurpose This study aims to evaluate relationship might exist between new indices of structural damage provided by FD‐OCT which analyses macular ganglion cell complex (mGCC) and functional indices collected in standard automated perimetry (SAP).Methods 102 eyes (56 PAOG and 46 control) benefited a SAP(Humphrey SITA‐Standard 24.2, Carl Zeiss Meditec) and an FD‐OCT imaging (RTVue 100, macular grid of 7*7mm, Optovue Inc.). We analyse: MD, PSD and VFI for functional analysis, and focal and global losses (FLV and GLV) of mGCC for macular mapping. Statistical regression analysis was used to assess possible structure‐function relationship.Results Glaucoma (66.2±3.5y) results report: MD:‐6.25±1.46dB, PSD:5.9±1.1dB, VFI:84±4.7%, FLV:4.84±1.26% and GLV:19.2±2.7%. Controls (61.6±4y) results were: MD:0.36±0.22dB, PSD:1.6 ± 0.1dB, VFI:99±0.5%, FLV:2.04±0.59 and GLV:9.8±2.3%. Structural damage and functional impairment indices may be correlated by linear regression. Correlation is higher in glaucoma group. Strongest relation is between PSD and FLV with determination coefficient (r ²) of 0,63.Conclusion This study evaluates the possible relationship between new structural and functional parameters in 2 age‐matched groups. Linear correlation, greater in glaucoma group, emphasizes a structure‐function relationship with a highest determination coefficient of 0,63. This correlation is between focal indices of structural and functional damage (PSD and FLV). New FD‐OCT parameters of mGCC provided us a better understanding of glaucoma structural damage. Assessment of structure‐function relationship is improved and we find a higher correlation between focal indices.