Abstract
AbstractHydrogels based on poly(ethylene oxide) (PEO) are suitable materials for numerous biomedical applications. Among the different ways to design such hydrogels, homopolymerization of bifunctional PEO macromonomers represents a promising approach. The present work discusses the extension of this crosslinking procedure to prepare degradable hydrogels. Poly(1,3‐dioxolane) (PDXL) hydrogels were synthesized directly in water (or in organic solvents) by free‐radical homopolymerization of α,ω‐methacryloyloxy PDXL macromonomers. They were investigated as gels swollen to equilibrium in THF CH2Cl2 or in water. In each case, the amount of extractable material, the extent of equilibrium swelling and the uniaxial compression modulus were determined. Nethertheless, PDXL chains contain acetal groups sensitive to acidic degradation. Hydrogels constituted of hydrophilic poly(ethylene oxide) (PEO) chains containing a short central PDXL block were obtained from α,ω‐methacryloyloxy PEO‐block‐1,3‐PDXL‐block‐PEO macromonomers. The variation of the mechanical properties of pure PDXL networks, when placed in acidic media, was followed by uniaxial compression modulus measurements.© 2002 Society of Chemical Industry
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
