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Abstract
trans-Cinnamic acid and its derivatives were investigated for the α-glucosidase inhibitory activity. 4-Methoxy- trans-cinnamic acid and 4-methoxy- trans-cinnamic acid ethyl ester showed the highest potent inhibitory activity among those of trans-cinnamic acid derivatives. The presence of substituents at 4-position in trans-cinnamic acid altered the α-glucosidase inhibitory activity. Increasing of bulkiness and the chain length of 4-alkoxy substituents as well as the increasing of the electron withdrawing group have been shown to decrease the inhibitory activity. 4-Methoxy- trans-cinnamic acid was a noncompetitive inhibitor for α-glucosidase, whereas, 4-methoxy- trans-cinnamic acid ethyl ester was a competitive inhibitor. These results indicated that trans-cinnamic acid derivatives could be classified as a new group of α-glucosidase inhibitors.
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