Abstract
A series of cis and trans configured 2,3,4,4a,5,10b-hexahydro-benz[h]isoquinoline-6(1H)-ones 2 were studied with respect to the binding affinity to the 5-HT2 subtype receptors. The influence of substituents in positions 7(R1), 8(R2) and 9(R3) on affinity and selectivity to 5-HT2A and 5-HT2C receptors and the preference of one diastereoisomer is discussed.
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