Structure-retention studies of model ketones by capillary gas chromatography

Abstract

The retention indices ( I) for a number of ketones were determined using linear temperature-programmed capillary gas chromatography. 2-Ketones were used as standards for the index calculations. The 95% confidence interval for triplicate determinations was found to be ± 0. 13 index unit. These retention indices and the zero-, first-, and second-order molecular connectivity factors for each compound were treated with multiple regression to yield equations to predict I. An interesting trend in the retention of symmetric ketones was noticed and rationalized on the basis of shielding of the carbonyl oxygen.