Abstract
Competition experiments have been performed to determine the relative reactivities of substituted bromobenzenes and of different arylzinc reagents in the [Pd(PPh(3))(4)]-catalyzed Negishi cross-coupling reaction in THF at 25 degrees C. The cross-coupling reactions are accelerated by electron acceptors in the bromobenzenes, the effect of which increases in the order ortho <meta <para. On the other hand, electron acceptors in the arylzinc halides diminish the reaction rates. Hammett correlations show that substituent variations in the bromobenzenes (rho=+2.5) have a larger effect than substituent variations in the arylzinc halides (rho=-0.98).
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