Abstract
Lipid droplets (LDs) are ubiquitous storage organelles for neutral lipids, mainly triacylglycerols and steryl esters. LDs have a unique structure consisting of a phospholipid monolayer enclosing a neutral lipid core. LDs form at the endoplasmic reticulum (ER) by unclear mechanisms. In the most popular model, LDs assemble at discrete ER domains by the budding of neutral lipid lenses formed in between of the two leaflets of the ER bilayer. Seipin has emerged as a key LD biogenesis factor and mutations are responsible for lipodystrophy in humans.
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