Abstract
Based on the crystal structure of the budding yeast Kluyveromyces lactis (Kl) Scm3–Cse4–H4 complex and the proteolysis results of the budding yeast Saccharomyces cerevisiae (Sc) Scm3–Cse4–H4 complex, Cho and Harrison (1) questioned our NMR structure of the Sc Scm3–Cse4–H4 complex (2), stating that “The construct deleted helix I of H4, however, and this deletion, together with omission of about 20 residues in the N-terminal part of the conserved region of Scm3, appears to have generated severe distortions in about half the structure, leading to incorrect conclusions about histone conformational differences and about a number of the Scm3-Cse4 contacts.”
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
