Abstract
Study of dipole moments of 3,5-dicyanopyrridine derivatives II-IV has shown that cyclocondensation of 3-aminocrotononitrile with esters of alkoxymethylenecyanoacetic acid gives the2-pyridone derivative I which can be transformed in 2-chloro- or 2-bromo derivatives IV and V by action of the respective halogenation agents. The substance IV is conversed into 2-iodo- and 2-dimethylamino derivatives VI and VII on action of HI and dimethylformamide, respectively. Alkylation of the 2-pyridone I with methyl iodide takes place at nitrogen atom to give the compound IX. The 1,4-dihydropyridine derivative X has been obtained by action of NaBH4 on IV.
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More From: Collection of Czechoslovak Chemical Communications
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