Abstract
EPR spectra of radicals derived from the three isomeric trihydroxypyrimidines and from 2-hydroxypyrimidine were obtained either in reduction or oxidation conditions at various pH values. Additionally, three other pyrimidine derivatives, 2-thiobarbituric acid, 2-amino-4,6-dihydroxypyrimidine and 2-methyl-4,5,6-trihydroxypyrimidine, were studied in the same conditions. Reduced radicals were produced by reaction of the pyrimidines with the hydrated electron, the hydrogen atom and with the CO2˙− radical. In these conditions, the electron adducts as well as CO2˙− adducts were identified in most cases. Oxidized radicals were obtained by reaction of the substrates with OH˙, O˙−, SO4˙−, and Br2˙− radicals. The radicals detected and studied were either of the OH-adduct type or radicals derived from its dehydration. The radicals were investigated by using in situ radiolysis and photolysis EPR techniques.
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