Abstract
ABSTRACT Vertical sections of colonies and confluent sheets of normal and polyoma virus-transformed BHK21 cells, and of a spontaneous malignant variant of BHK21 cells, and also of freshly isolated hamster fibroblasts, were examined to determine the structural interrelationship of the cells in relation to their varying transplantability. All cells except the freshly isolated fibroblasts formed multilayers, but the virus-transformed cells were arranged in the form of a loose network, in which cell division took place. The untransformed BHK21 cells were very tightly packed and mitosis was rare. A spontaneous malignant variant which superficially resembled the normal BHK21 cells was shown by section to have features in common with virus-transformed cells.
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