STRUCTURE OF MORBIDITY AND CLINICAL ENDOSCOPIC INDICES OF CELIAC DISEASE PATIENTS

Abstract

This article focuses on the study of the clinical picture, treatment and prevention of celiac disease in children. Celiac disease is the one of the most pressing problems in clinical pediatrics and gastroenterology due to its wide prevalence, the complexity of pathogenesis, difficulties of diagnosis and the polymorphism of the clinical picture. A detailed analysis of the history cases of 292 children celiac disease patients admitted to the gastroenterological department of N.M. Kuraev Dagestan Republic Clinical Hospital during 2011-2014 is presented. An analysis of the prevalence of the disease depending on climatic and geographical factors showed 207 patients (71%) to reside in rural areas, 85 children (29%) - in urban areas. Out of them, celiac disease was detected in 24% of lowlanders, 16% in the foothills residents and 30% - in the mountain population. Typical clinical manifestations of the disease in children are described. Significant deteriorations of the intestinal microbiota in all the celiac disease patients were detected. The authors believe that despite long-term compliance with the gluten-free diet and visible social adaptation, examined children show different forms of pathology of the gastrointestinal tract and other systems, which indicates to the need for lifelong clinical follow-up.