Abstract
The binding of pyelonephritogenic Escherichia coli strains to human uroepithelial cells from patients with and without P blood group antigens was investigated. Uroepithelial cells from p̄ phenotypes bound pyelonephritogenic E. coli to a significantly lesser extent than did cells from P1 or P2 phenotypes. The binding of pyelonephritogenic E. coli to urinary epithelial cells of P1 phenotypes was blocked by the synthetic disaccharide α-D-Galp-(1→4)-β-D-Galp whose structure is related to that of the P blood group antigens. Coating of P1 cells with a synthetic disaccharide derivative increased the binding of bacteria. None of 30 individuals of p̄ phenotype had had urinary tract infection. The findings show that the disaccharide α-D-Galp-(1→4)-β-D-Galp, previously shown to be the erythrocyte receptor for the fimbriae of pyelonephritogenic E. coli, is also the receptor structure on uroepithelial cells.
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