Abstract
The mechanism of conversion of virion RNA to doublestranded DNA, in avian sarcoma virus-infected duck cells, has been investigated. The evidence presented here indicates a covalent linkage between the genomic RNA and the newly synthesized is primed by the 35S virion RNA. Some data identifying the virus specific hybrid and linear double-stranded DNA molecules, which are probably intermediates, leading to the formation of supercoiled duplex viral DNA, has also been presented.
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