Abstract
Bioassay-guided fractionation of the cytotoxic acid hydrolysate of the total ginsenosides of Panax ginseng C. A. Meyer (Araliaceae) afforded a new ginsenoside, (20S,22S)-dammar-22,25-epoxy-3β,12β,20-triol (1), along with five known ginsenosides, 20R,24R-dammar-20(24)-epoxy-3β,12β,25-triol (2), 20R-panaxdiol (3), dammar-(E)-20(22)-ene-3β,12β,25-triol (4), 20R-protopanaxadiol (5), and 20R-dammar-25-ethoxy-3β,12β,20-triol (6). Their structures were elucidated on the basis of spectroscopic data. Among the compounds isolated, compound 1 showed strong cytotoxic activity against human cancer cell lines SW1116, HCT116, and A549.
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