Abstract
Folate vitamins are essential for DNA replication and cellular proliferation. However, mammalian organisms are devoid of folate biosynthesis and rely on dietary sources to meet their metabolic requirement for folate cofactors. The proton coupled folate transporter (PCFT/SLC46A1) has been recently identified as the molecular entity responsible for intestinal folate uptake displaying optimal transport activity at acidic pH. PCFT is also involved in transport of chemotherapeutically used antifolates.
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